What serum level of 25-hydroxyvitamin D reduces episodes of asthma exacerbation in childhood and adolescence?
Main Article Content
Abstract
Introduction: Asthma is a disease characterized by chronic
inflammation of the airways. Vitamin D is a hormone with
several physiological actions. Its immunomodulatory role
targets various imune cells. These effects make it a critical
regulator of immune system function, the deficiency of
which can predispose to asthma and allergies in the presence
of other environmental stimuli. Objective: This study aims
to evaluate, through a non-systematic literature review, the
association between serum levels of 25-hydroxyvitamin D
and asthma exacerbations in childhood and adolescence.
Methodology: Studies published in English were analyzed
concerning the PUBMED database. Controlled and
randomized clinical trials, meta-analyses, and literature
reviews were included. Results: The main studies and their
results showed that vitamin D deficiency was related to
a greater possibility of asthma exacerbations. Vitamin D
has potent immunomodulatory properties that can inhibit
airway inflammation. Patients who received doses of vitamin
D had fewer exacerbations and achieved better and earlier
asthma control. The need for steroids was significantly
reduced. Conclusions: This review supports the relationship
between low serum 25-hydroxyvitamin D levels, worsening
lung function, and increased asthma exacerbations. However,
larger, well-designed randomized clinical trials are needed
to confirm these conclusions and to investigate the optimal
vitamin D regimen and the patients who would most benefit
from supplementation.
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