Neonatal alloimmune thrombocytopenia as a cause of fetal intracranial hemorrhage: Case report
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Abstract
The production of maternal antibodies against fetal platelet antigens inherited from the father, which generates significant platelet destruction, defines neonatal alloimmune thrombocytopenia. It is characterized by intense thrombocytopenia, with significant postnatal mucocutaneous bleeding, in addition to being an important cause of neurological sequelae in newborns resulting from intracranial hemorrhage that occurs both intrauterine and perinatally. Because it is underdiagnosed in clinical practice, we sought to report the clinical case in order to discuss the diagnosis, clinical management and importance of neonatal alloimmune thrombocytopenia, which presented with fetal intracranial bleeding evidenced during prenatal ultrasound evaluation.
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References
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