Probióticos e prebióticos na cólica infantil: uma revisão sistemática

Conteúdo do artigo principal

Laís Helena Valio Simionato
Isabella Gonçalves Grandini Silas
Hamida Abdul Basset Malat
Georgia Oger Garcia
Matheus Alves Alvares
Vera Esteves Vagnozzi Rullo

Resumo

Introdução: A cólica infantil é um dos distúrbios de maior incidência nos primeiros quatro meses de vida, afetando cerca de 20% dos lactentes. Ela ainda não possui um tratamento
definitivo, apenas medidas de alívio dos sintomas. Objetivo: Esta revisão visa avaliar os ensaios clínicos randomizados presentes na literatura, quanto à utilização dos probióticos
e prebióticos na cólica infantil em lactentes. Fontes de dados: A revisão sistemática se deu através da seleção de artigos no Sistema Online de Busca e Análise de Literatura Médica
(MEDLINE), via Pubmed e Scielo. Síntese dos dados: Dois desfechos se destacaram: a duração do choro diário e incidência de cólica. Foram selecionados 23 estudos, dos quais 13
avaliaram a duração do choro diário, demonstrando redução estatisticamente relevante em relação ao grupo controle; e cinco avaliaram a incidência de cólica, observando igualmente redução significativa no grupo experimental. Conclusão: O Lactobacillus reuteri DSM 17938 destaca-se em relação aos demais métodos testados quanto ao manejo clínico da cólica infantil, com redução do tempo de choro, incidência de cólica e demais desfechos. As
fórmulas especializadas (como as hidrolisadas ou fermentadas) são consideradas a segunda melhor intervenção disponível. As demais intervenções não demonstram sucesso na literatura, embora o tenham feito neste trabalho, e carecem de maiores estudos acerca de sua aplicabilidade. 

Downloads

Não há dados estatísticos.
👁 Abstract Views: 101📥 PDF PT Downloads: 5

Detalhes do artigo

Como Citar
Laís Helena Valio Simionato, Isabella Gonçalves Grandini Silas, Hamida Abdul Basset Malat, Georgia Oger Garcia, Matheus Alves Alvares, & Vera Esteves Vagnozzi Rullo. (2021). Probióticos e prebióticos na cólica infantil: uma revisão sistemática. Revista De Pediatria SOPERJ, 21(3), 139–149. https://doi.org/10.31365/issn.2595-1769.v21i3p139-149
Seção
Artigo de Revisão

Referências

1. Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, et al. Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics. 2010;126(3):e526-533. https://pediatrics.aappublications.org/content/126/3/e526. Acesso: 01/08/2020.

2. Savino F, Pelle E, Palumeri E, Oggero R, Miniero R. Lactobacillus reuteri (American Type Culture Collection Strain 55730) versus simethicone in the treatment of infantile colic: a prospective randomized study. Pediatrics. 2007;119(1):e124-130. https://pediatrics.aappublications.org/content/119/1/e124. Acesso: 01/08/2020.

3. Blesa Baviera LC. Trastornos digestivos funcionales pediátricos. Criterios Roma IV. In: AEPap (ed.). Curso de Actualización Pediatría 2017. Madrid: Lúa Ediciones 3.0; 2017. p. 99-114.

4. Sung V, Hiscock H, Tang ML, Mensah FK, Nation ML, Satzke C, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014;348:g2107. https://www.bmj.com/content/348/bmj.g2107. Acesso: 01/08/2020.

5. Giglione E, Prodam F, Bellone S, Monticone S, Beux S, Marolda A, et al. The Association of Bifidobacterium breve BR03 and B632 is Effective to Prevent Colics in Bottle-fed Infants: A Pilot, Controlled, Randomized, and Double-Blind Study. J Clin Gastroenterol. 2015;5(2):164-167. https://journals.lww.com/jcge/Fulltext/2016/11001/The_Association_of_Bifidobacterium_breve_BR03_and.17.aspx. Acesso: 01/08/2020.

6. Giovannini M, Verduci E, Gregori D, Ballali S, Soldi S, Ghisleni D, et al. Prebiotic effect of an infant formula supplemented with galacto-oligosaccharides: randomized multicenter trial. J Am Coll Nutr. 2014;33(5):385-393. https://www.tandfonline.com/doi/abs/10.1080/07315724.2013.878232. Acesso: 01/08/2020.

7. Nation ML, Dunne EM, Joseph SJ, Mensah FK, Sung V, Satzke C, et al. Impact of Lactobacillus reuteri colonization on gut microbiota, inflammation, and crying time in infant colic. Sci Rep. 2017;7(1):15047. https://www.nature.com/articles/s41598-017-15404-7. Acesso: 01/08/2020.

8. Mi GL, Zhao L, Qiao DD, Kang WQ, Tang MQ, Xu JK. Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial. Antonie Van Leeuwenhoek. 2015;107(6):1547-1553. https://link.springer.com/article/10.1007/s10482-015-0448-9. Acesso: 10/08/2020.

9. Pärtty A, Lehtonen L, Kalliomäki M, Salminen S, Isolauri E. Probiotic Lactobacillus rhamnosus GG therapy and microbiological programming in infantile colic: a randomized, controlled trial. Pediatr Res. 2015;78(4):470-475. https://www.nature.com/articles/pr2015127. Acesso: 01/08/2020.

10. Roberfroid, MB. Prebiotics: preferential substrates for specific germs? Am. J. Clin. Nutr. 2001; 73 (2):406-409. https://academic.oup.com/ajcn/article/73/2/406s/4737570. Acesso: 10/08/2020.

11. Gilliland SE. Probiotics and prebiotics. In: Marth EH, Steele JL, eds. Applied Dairy Microbiology. New York: Marcel Dekker; 2001. p.327-343.

12. Mattila-Sandholm T, Myllärinen P, Crittenden R, Mogensen G, Fondén R, Saarela M. Technological challenges for future probiotic foods. Int. Dairy J. 2002; 12(2):173-182. https://europepmc.org/article/agr/ind23320686. Acesso: 10/08/2020.

13. Report of a Joint of Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation on Evaluation of Health and Nutrition Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria. Probiotics in food - Health and Nutritional Properties and Guidelines for Evaluation. 2001, Córdoba, Argentina. [S. l.: s. n.], 2001. http://www.fao.org/3/a-a0512e.pdf. Acesso: 01/08/2020.

14. Who.int [site na internet]. New York: World Health Organization, Inc. https://www.who.int/. Acesso: 10/08/2020.

15. Sanders, ME. Probiotics: considerations for human health. Nutr. Rev. 2003; 61(3): 91-99. https://academic.oup.com/nutritionreviews/article/61/3/91/1865418. Acesso: 10/08/2020.

16. Puupponen-Pimiä R, Aura AM, Oksman-Caldentey KM, Myllärinen P, Saarela M, Mattila-Sanholm T, et al. Development of functional ingredients for gut health. Trends Food Sci. Technol. 2002; 13(1):3-11. https://www.sciencedirect.com/science/article/abs/pii/S0924224402000201?via%3Dihub Acesso: 10/08/2020.

17. Sung V, Hiscock H, Tang M, Mensah FK, Heine RG, Stock A, et al. Probiotics to improve outcomes of colic in the community: protocol for the Baby Biotics randomised controlled trial. BMC Pediatr. 2012;135(12). https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-135. Acesso: 01/08/2020.

18. Vivatvakin B, Mahayosnond A, Theamboonlers A, Steenhout PG, Conus NJ. Effect of a whey-predominant starter formula containing LCPUFAs and oligosaccharides (FOS/GOS) on gastrointestinal comfort in infants. Asia Pac J Clin Nutr. 2010;19(4):473-480. https://pubmed.ncbi.nlm.nih.gov/21147707/. Acesso: 01/08/2020.

19. Scottish Intercollegiate Guidelines Network. SIGN 50. A Guideline Developers' Handbook. Edinburgh, February 2001.

20. Ellwood J, Draper-Rodi J, Carnes D. Comparison of common interventions for the treatment of infantile colic: a systematic review of reviews and guidelines. BMJ Open. 2020;10(2):e035405. https://bmjopen.bmj.com/content/10/2/e035405. Acesso: 15/09/2020.

21. Gutiérrez-Castrellón P, Indrio F, Bolio-Galvis A, Jiménez-Gutiérrez C, Jimenez-Escobar I, López-Velázquez G. Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis. Medicine. 2018; 96(51): e9375. https://journals.lww.com/md-. Acesso: 15/09/2020.

22. Sung V, D'Amico F, Cabana MD, Chau K, Koren G, Savino F, Szajewska H, et al. Lactobacillus reuteri to Treat Infant Colic: A Meta-analysis. Pediatrics. 2018;141(1):e20171811. https://pediatrics.aappublications.org/content/141/1/e20171811. Acesso: 15/09/2020.

23. Hjern A, Lindblom K, Reuter A, Silfverdal SA. A systematic review of prevention and treatment of infantile colic. Acta Paediatr. 2020;109(9):1733-1744. https://onlinelibrary.wiley.com/doi/full/10.1111/apa.15247. Acesso: 15/09/2020.

24. Sung V. Probiotic interventions in infantile colic. Curr Opin Clin Nutr Metabol Care. 2015;18(3):307-311.https://journals.lww.com/co-clinicalnutrition/Abstract/2015/05000/Probiotic_interventions_in_infantile_colic.16.aspx. Acesso: 15/09/2020.

25. Moreira AC, Castro JC, Barreira JF, Coimbra R. Tratamento da cólica infantil: uma revisão baseada na evidência. Rev Port Med Geral Fam. 2019;35(5):367-380. http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S2182-51732019000500004&lng=pt. Acesso: 15/09/2020.

26. Cruchet S, Furnes R, Maruy A, Hebel E, Palacios J, Medina F, et al. The use of probiotics in pediatric gastroenterology: a review of the literature and recommendations by Latin-American experts. Paediatr Drugs. 2015;17(3):199-216. https://link.springer.com/article/10.1007%2Fs40272-015-0124-6. Acesso: 15/09/2020.

27. Pärtty A, Rautava S, Kalliomäki M. Probiotics on Pediatric Functional Gastrointestinal Disorders. Nutrients. 2018;10(12):1836. https://www.mdpi.com/2072-6643/10/12/1836. Acesso: 15/09/2020.

28. Karkhaneh M, Fraser L, Jou H, Vohra S. Effectiveness of probiotics in infantile colic: A rapid review. Paediatr Child Health. 2020;25(3):149-159. https://academic.oup.com/pch/article-abstract/25/3/149/5426479?redirectedFrom=fulltext. Acesso: 15/09/2020.

29. Vandenplas Y, Ludwig T, Bouritius H, Alliet P, Forde D, Peeters S, et al. Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic. Acta Paediatr. 2017;106(7):1150-1158. https://onlinelibrary.wiley.com/doi/full/10.1111/apa.13844. Acesso: 15/09/2020.

30. Cabana MD, McKean M, Beck AL, Flaherman V. Pilot Analysis of Early Lactobacillus rhamnosus GG for Infant Colic Prevention. J Pediatr Gastroenterol Nutr. 2019;68(1):17-19. https://journals.lww.com/jpgn/Fulltext/2019/01000/Pilot_Analysis_of_Early_Lactobacillus_rhamnosus_GG.5.aspx. Acesso: 10/08/2020.

31. Indrio F, Di Mauro A, Riezzo G, Civardi E, Intini C, Corvaglia L et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr. 2014;168(3):228-233. https://jamanetwork.com/journals/jamapediatrics/fullarticle/1812293. Acesso: 10/08/2020.

32. Savino F, Galliano I, Garro M, Savino A, Daprà V, Montanari P, et al. Regulatory T cells and Toll-like receptor 2 and 4 mRNA expression in infants with colic treated with Lactobacillus reuteri DSM17938. Benef Microbes. 2018;9(6):917-925. https://www.wageningenacademic.com/doi/10.3920/BM2017.0194. Acesso: 10/08/2020.

33. Martinelli M, Ummarino D, Giugliano FP, Sciorio E, Tortora C, Bruzzese D et al. Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial. Neurogastroenterol Motil. 2017;29(12)e13145. https://onlinelibrary.wiley.com/doi/abs/10.1111/nmo.13145. Acesso: 10/08/2020.

34. Baldassarre ME, Di Mauro A, Tafuri S, Rizzo V, Gallone MS, Mastromarino P et al. Effectiveness and Safety of a Probiotic-Mixture for the Treatment of Infantile Colic: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial with Fecal Real-Time PCR and NMR-Based Metabolomics Analysis. Nutrients. 2018;10(2):195. https://www.mdpi.com/2072-6643/10/2/195. Acesso: 10/08/2020.

35. Vandenplas Y, Bacarea A, Marusteri M, Bacarea V, Constantin M, Manolache M. Efficacy and safety of APT198K for the treatment of infantile colic: a pilot study. J Comp Eff Res. 2017;6(2):137-144. https://www.futuremedicine.com/doi/10.2217/cer-2016-0059. Acesso: 10/08/2020.

36. Fatheree NY, Liu Y, Taylor CM, Hoang TK, Cai C, Rahbar MH et al. Lactobacillus reuteri for Infants with Colic: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. J Pediatr. 2017;191:170-178. https://www.jpeds.com/article/S0022-3476(17)31039-9/fulltext. Acesso: 10/08/2020.

37. Savino F, Garro M, Montanari P, Galliano I, Bergallo M. Crying Time and RORγ/FOXP3 Expression in Lactobacillus reuteri DSM17938-Treated Infants with Colic: A Randomized Trial. J Pediatr. 2018;192:171-177. https://www.jpeds.com/article/S0022-3476(17)31143-5/fulltext. Acesso: 10/08/2020.

38. Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind, placebo-controlled trial. J Pediatr. 2013;162(2):257-262. https://www.jpeds.com/article/S0022-3476(12)00920-1/fulltext. Acesso: 10/08/2020.

39. Roos S, Dicksved J, Tarasco V, Locatelli E, Ricceri F, Grandin U et al. 454 pyrosequencing analysis on faecal samples from a randomized DBPC trial of colicky infants treated with Lactobacillus reuteri DSM 17938. PLoS ONE. 2013;8(2):e56710. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056710. Acesso: 10/08/2020.

40. Savino F, Ceratto S, Poggi E, Cartosio ME, Cordero di Montezemolo L, Giannattasio A. Preventive effects of oral probiotic on infantile colic: a prospective, randomised, blinded, controlled trial using Lactobacillus reuteri DSM 17938. Benef Microbes. 2015;6(3):245-251. https://www.wageningenacademic.com/doi/10.3920/BM2014.0090. Acesso: 10/08/2020.

41. Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N et al. Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. J Pediatr. 2015;166(1):74-78. https://www.jpeds.com/article/S0022-3476(14)00848-8/fulltext. Acesso: 10/08/2020.

42. Rodriguez-Herrera A, Mulder K, Bouritius H, Rubio R, Muñoz A, Agosti M et al. Gastrointestinal Tolerance, Growth and Safety of a Partly Fermented Formula with Specific Prebiotics in Healthy Infants: A Double-Blind, Randomized, Controlled Trial. Nutrients. 2019;11(7):1530. https://www.mdpi.com/2072-6643/11/7/1530. Acesso: 10/08/2020.

43. Gerasimov S, Gantzel J, Dementieva N, Schevchenko O, Tsitsura O, Guta N et al. Role of Lactobacillus rhamnosus (FloraActiveT) 19070-2 and Lactobacillus reuteri (FloraActiveT) 12246 in Infant Colic: A Randomized Dietary Study. Nutrients. 2018;10(12):1975. https://www.mdpi.com/2072-6643/10/12/1975. Acesso: 10/08/2020.

44. Dupont C, Rivero M, Grillon C, Belaroussi N, Kalindjian A, Marin V. Alpha-lactalbumin-enriched and probiotic-supplemented infant formula in infants with colic: growth and gastrointestinal tolerance. Eur J Clin Nutr. 2010;64(7):765-767. https://www.nature.com/articles/ejcn201081. Acesso: 10/08/2020.

Artigos mais lidos pelo mesmo(s) autor(es)

Artigos Semelhantes

Você também pode iniciar uma pesquisa avançada por similaridade para este artigo.