Relationship between serum vitamin D levels and cow’s milk protein allergy in infants: a systematic review based on the prism method

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Published: Mar 6, 2020
DOI: https://doi.org/10.31365/issn.2595-1769.v20i2p59-66
Keywords:
Milk Hypersensitivity; Infant; Vitamin D; Immune System; Sunlight.

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Heloísa Toledo Garcia
Unifesp
Dayane Pêdra Batista De Faria Batista-De Faria
Unifesp

Abstract

Introduction: Cows milk protein allergy (CMPA) manifests most often in infants. Dietary exclusion of cows milk proteins may lead to energy and nutrient deficiencies such as vitamin D. Objective: To verify the development of CMPA and its relationship between serum vitamin D levels in infants. Data source: Systematic review according to the PRISMA method was performed in the PubMed, Lilacs and Scielo databases from March to July 2018. Selected clinical trials with infants addressing the theme of CMPA and their relationship with levels were selected for reading. vitamin D serum Consulted the reference list of the selected articles and analyzed by two authors for the final extraction of information. Data synthesis: We found 115 articles, 12 selected for reading and 4 included for analysis. Two articles evaluated serum vitamin D levels in infants diagnosed with CMPA compared to the healthy control group; an article evaluated the serum vitamin D level of the umbilical cord in infants sensitized to cows milk proteins and one article evaluated the serum vitamin D level in infants with atopic dermatitis who presented mono or polysensitization to food allergens, among them cow milk. Conclusions: Few studies have investigated the relationship between serum vitamin D levels and CMPA development. Due to the clinical importance of this condition, further studies are required to relate these variables in order to contribute to better treatments for the diagnosed population.

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Heloísa Toledo Garcia, & Dayane Pêdra Batista De Faria Batista-De Faria. (2020). Relationship between serum vitamin D levels and cow’s milk protein allergy in infants: a systematic review based on the prism method. Revista De Pediatria SOPERJ, 20(2), 59–66. https://doi.org/10.31365/issn.2595-1769.v20i2p59-66
Issue
Vol. 20 No. 2 (2020): Abr. Maio. Jun.
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Artigo de Revisão
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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