Fever of unknown origin in pediatrics: uniting clinical tradition and diagnostic innovation
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Abstract
[The article “Epidemiological Description of Patients with Fever of Unknown Origin in a Pediatric Hospital in Brazil,” by Guimarães and Carvalho, published in this issue of the SOPERJ Journal of Pediatrics, makes a significant contribution by highlighting the real challenges faced in investigating prolonged episodes of fever of unknown origin in children. In the study, more than half of the patients (52.4%) remained undiagnosed at the end of their hospitalization, despite evaluation at a tertiary care center with laboratory and imaging resources.]
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References
1. Chow A, Robinson JL. Fever of unknown origin in children: a systematic review. World J Pediatr. 2011;7(1):5-10.
2. Yu X, Liu Y, Zhou X, et al. Diagnostic efficacy of 18F-FDG PET/CT in fever of unknown origin: A cohort study. Front Med (Lausanne). 2025;11:1511710.
3. Hess S, Noriega-Álvarez E, Leccisotti L, Treglia G, Albano D, Roivainen A, Glaudemans AWJM, Gheysens O. EANM consensus document on the use of [18F]FDG PET/CT in fever and inflammation of unknown origin. Eur J Nucl Med Mol Imaging. 2024 Jul;51(9):2597-2613. doi: 10.1007/s00259-024-06732-8.
4. Graaf P, Boerman O, Claessens Y. Clinical and imaging approach in pediatric FUO: when and how to escalate. Pediatr Radiol. 2023;53(12):2155-64.
5. Pijl JP, Glaudemans AWJM, van Rheenen PF, et al. FDG-PET/CT in 110 children with fever of unknown origin: diagnostic yield and clinical utility. Eur J Nucl Med Mol Imaging. 2024;51(8):2744-55.