Necrotizing pneumonia and its outcomes in a pediatric hospital in Southern Brazil
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Abstract
Introduction: Necrotizing pneumonia is a rare and severe complication of community-acquired pneumonia, affecting mainly immunocompetent preschool children. Objective: Analyze the epidemiological profile of the disease and its outcomes in a pediatric hospital in southern Brazil. Method: This is an observational, retrospective and cohort study; with descriptive character, that analyzes the patients with diagnosis of necrotizing pneumonia in a pediatric hospital in the south of the country from January 2013 to December 2020. Results: Considering an overall of 4,538 patients, the prevalence of necrotizing pneumonia was 86 patients (1.89%). Clinical treatment was performed in 52.3% of patients, while surgical treatment in 47.7%. The mean antibiotic use per patient was 3.05 antibiotics, ranging from 1 to 11 different types of them. Complications represented 91.9% of the cases, and a total of 50% of the patients were admitted to the intensive care unit. At the end of the study, one patient died. Conclusion: This analysis showed that patients with necrotizing pneumonia require prolonged hospitalization time, multiple antibiotic therapy regime and complementary surgical interventions for those who developed complications. Despite this, it evolved with favorable outcomes, resulting in low mortality, good prognosis, but high treatment complexity.
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References
1. WHO [internet]. Newsroom: Pneumonia, [updated 11 novembro 2021; citado 27 janeiro 2022]. Disponível em: https://www.who.int/news-room/fact-sheets/detail/pneumonia
2. Masters I, Isles AF, Grimwood K. Necrotizing pneumonia: an emerging problem in children?. Pneumo. 2017;9:11.
3. Hsieh YC, Hsiao CH, Tsao PN, Wang JY, Hsueh PR, Chiang BL, Huang LM.Necrotizing pneumococcal pneumonia in children: The role of pulmonary gangrene. Pediatr Pulmonol. 2006;41(7):623-629.
4. Sharma PK, Vinayak N, Aggarwal GK, Srivastana RD, Aggarwal PK, Kushwaha AS. Severe Necrotizing Pneumonia in Children: A Challenge to Intensive Care Specialist. J Trop Pediatr. 2020;66:637-644.
5. Krenke K, Sanocki M, Urbankowska E, Kraj G, Krawiec M, Urbankowski T, et al. Necrotizing Pneumonia and Its Complications in Children. Adv Exp Med Biol. 2015;857:9-17.
6. Lai JY, Yang W, Ming YC. Surgical Management of Complicated Necrotizing Pneumonia in Children. Pediatr Neonatol. 2017;58(4):321-327.
7. Blanco-Iglesias E, Oñoro G, Almodovar-Martín JL, García-Salido A, De Lama Caro-Patón G, Martínez de Azagra-Garde A, et al. Retrospective Study in Children With Necrotizing Pneumonia: Nine Years of Intensive Care Experience. Pediatr Infect Dis J. 2020 Jul;39(7):571-575.
8. Machado K, Badía F, Assandri E, Gutiérrez C, Motta I, Varela A, et al. Neumonía necrotizante en niños: 10 años de experiencia en un hospital pediátrico de referencia. Arch Pediatr Urug. 2020;91(5):294-302.
9. Nicolaou EV, Bartlett AH. Necrotizing Pneumonia. Pediatr Ann. 2017;46(2):65-68.
10. Westphal FL, Lima LC, Netto JCL, Tavares E, Andrade EO, Silva MS. Tratamento cirúrgico de crianças com pneumonia necrosante. J Bras Pneumol. 2010;36(6):716-723.
11. Dalponte RS, Heluany GCV, Michels M, Madeira K, Prado CE. Tratamento cirúrgico de pneumonia necrosante em crianças em um período de 10 anos. Rev Col Bras Cir. 2020;47:e20202374.
12. Alves JCT, Lopes CRC, Guzzi GP, Pinto MV, Ribeiro LMM, Silva SBIM, et al. Impacto da pandemia de COVID-19 na epidemiologia pediátrica. Resid Pediatr. 2020;10(3):1-4
13. De Benedictis FM, Kerem E, Chang AB, Colin AA, Zar HJ, Bush A. Complicated pneumonia in children. Lancet. 2020;396(10253):786-798.
14. Lemaître C, Angoulvant F, Gabor F, Makhoul J, Bonacorsi S, Naudin J, et al. Necrotizing Pneumonia in Children. Pediatr Infect Dis J. 2013;32(10):1146-1149.
15. Sawicki GS, Lu FL, Valim C, Cleveland RH, Colin AA. Necrotising pneumonia is an increasingly detected complication of pneumonia in children. Eur Respir J. 2008;31:1285-1291.
16. Islam S, Calkins CM, Goldin AB, Chen C, Downard CD, Huang EY, et al. APSA Outcomes and Clinical Trials Committee, 2011-2012. The diagnosis and management of empyema in children: a comprehensive review from the APSA Outcomes and Clinical Trials Committee. J Pediatr Surg. 2012;47(11):2101-10.
17. Moreno-Pérez D, Andrés Martín A, Tagarro García A, Escribano Montaner A, Figuerola Mulet J, García García JJ, et al. Community acquired pneumonia in children: Treatment of complicated cases and risk patients. Consensus statement by the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Chest Diseases (SENP). An Pediatr (Barc). 2015;83(3):217e1-217e11.
18. Knebel R, Fraga JC, Amantéa SL, Isolan PBS. Videothoracoscopic surgery before and after chest tube drainage for children with complicated parapneumonic effusion. J Pediatr. 2018; 94(2):140-145.
19. Wong KS, Chiu CH, Yeow KM, Huang YC, Liu HP, Lin TY. Necrotising pneumonitis in children. Eur J Pediatr. 2000;159:684-688.